Progesterone and Mental Health – God’s Defense System

Written by Mandi Snell, APRN
Owner, Solutions Functional Medicine

Anxiety and depression are often treated with prescriptions, but sometimes the missing piece isn’t serotonin—it’s progesterone.

Progesterone has powerful effects in the brain. It interacts with receptors in the amygdala, helping to calm fear and regulate emotions. It supports clear thinking, restful sleep, and peace of mind. When levels drop, women often experience anxiety, depression, or mood swings.

Think of postpartum depression. After birth, progesterone plummets, and many women struggle with anxiety or deep sadness. Instead of simply treating symptoms with antidepressants, what many truly need is hormonal balance.

Scripture tells us in Philippians 4:7, “And the peace of God, which transcends all understanding, will guard your hearts and your minds in Christ Jesus.” God offers us supernatural peace, but He also equips us with natural tools like progesterone to support the mind He created.

Restoring progesterone doesn’t replace prayer or faith—it complements them. It’s one more way we can partner with God’s design for whole-person wellness.